Did I hear DS???
Gurch, the set up is rather simple... Here are some links that walk you through the setup.
First: Colors Website: http://www.collectingsmiles.com/colors
There's a FAQ section on the main page, just scroll down.
Here's a setup tutorial: http://conceptart.org/forums/showthread.php?t=109672
And finally, here's the colors gallery... They have amazing images, and one of the cool things about colors, is you can watch a person's pen strokes as he/she puts the image together... When you get Colors and start using it, you can also download and run a java program that allows you to do the same playback thingy, but it also can enlarge the image so you can save a version bigger than the dinky png default.
When you get your new toy, and if you have any questions, shoot me an e-mail or a message and I'll help you out.
I love having a digital sketchbook, and I highly recommend it to anyone (although my images are no where near as impressive as the ones you'll see at the gallery, it makes me happy).
Please check out my Colors! Gallery when you get a chance. -
http://colors.collectingsmiles.com/author.php?page=1&id=3427